Symptoms of stage III myeloma include skeletal destruction, abnormal bone marrow hematopoietic function, neurological symptoms, renal function impairment and other manifestations. 1. Skeletal destruction manifestations: including pain in the lumbar back, sternum, ribs, etc.; pathologic fracture of ribs, clavicle, thoracolumbar vertebrae, etc., post osteolysis hypercalcemia, and other manifestations. 2. Abnormal bone marrow hematopoietic function: including anemia, recurrent infection after leukopenia, abnormal bleeding due to abnormal coagulation, etc. 3. Neurological symptoms: including abnormal tingling sensation, numbness, tactile hypersensitivity and other manifestations. Meanwhile, pathologic fracture of spine can also lead to paraplegia and other serious nerve damage. 4. Kidney function impairment: symptoms such as decreased urine volume, increased foam in urine, change of urine color, and edema of face or lower limbs. If the above symptoms occur, it is recommended to go to the hospital in time.