Patients with penicillin allergy can take other drugs to treat syphilis, such as ceftriaxone sodium, tetracycline and macrolide antibiotics. Syphilis is a chronic infectious disease caused by syphilis spirochete infection, mainly through sexual contact, mother-to-child transmission, blood transmission, very harmful, will violate all organs of the body, or through the placenta caused by stillbirth, miscarriage, preterm delivery, fetal transmission of syphilis; the first choice of drugs is penicillin, if you are allergic to penicillin can be replaced with the following drugs. 1. Ceftriaxone sodium: in recent years, it has been proved that it can be used as a highly effective anti-syphilis drug, and it can be used as a preferred alternative therapeutic drug for penicillin-allergic patients, skin test should also be conducted before use, and it is forbidden to use it for those who are allergic to the drug. 2. Tetracyclines and macrolides: commonly used drugs tetracyclines are: minocycline, tetracycline, doxycycline, etc.; macrolides are azithromycin and so on. These two types of drugs are less effective than penicillin, and can be used as alternative treatment drugs for penicillin-allergic patients, with common adverse reactions of gastrointestinal irritation, and are prohibited for those who are allergic to the drug. The existence of syphilis spirochete resistance to macrolides, clinical generally rarely used. The syphilis should go to the regular hospital in time to check, follow the doctor’s instructions standardized treatment.