Treatment options for lupus nephritis type IV include immunosuppressive therapy and supportive care for associated manifestations and complications. Lupus nephritis type IV is an active or inactive lesion with a diffuse (50% or greater glomerular involvement) segmental or globular distribution. Intracapillary or extracapillary proliferative lesions may be present, accompanied by diffuse subendothelial immune complex deposition, with or without tethered proliferative lesions. 1. Immunosuppressive therapy: it should be determined according to clinical manifestations, serologic findings and histologic activity of renal lesions. Immunosuppressive therapy includes glucocorticoids and immunosuppressive agents. The former includes methylprednisolone and prednisone; immunosuppressive agents include hydroxychloroquine, mertiomacrophenol ester, cyclophosphamide, cyclosporine and so on. 2. Supportive treatment for related manifestations and complications: lupus nephritis belongs to chronic kidney disease, supportive treatment should also follow the principle of “integration”, strictly control hypertension, hyperlipidemia, etc., and adjust calcium and phosphorus metabolism. etc. Lupus nephritis type IV should go to the hospital in time and use medication under the guidance of professional physicians.