Lupus erythematosus usually refers to systemic lupus erythematosus, the etiology of which is mainly related to genetics, environmental factors, estrogen and other factors. Systemic lupus erythematosus (SLE) is an autoimmune disease in which pathogenic autoantibodies and immune complexes are formed and mediate organ and tissue damage. Clinically, there is often multi-system involvement, and a variety of autoantibodies, including antinuclear antibodies, are present in the serum. At present, it is believed that the disease is related to genetic, environmental factors, estrogen and other factors. 1. Heredity: SLE patients’ 1st generation relatives with SLE are 8 times more likely to suffer from SLE than families without SLE patients, and monozygotic twins with SLE are 5 to 10 times more likely to suffer from SLE than heterozygotic twins. Clinically, SLE patients often have relatives with other connective tissue diseases in their families. And the disease is polygenic related disease. 2. Environmental factors: sunlight, drugs, chemical reagents, microbial pathogens, etc. can lead to the development of systemic lupus erythematosus. 3. Estrogen: the prevalence of SLE is significantly higher in women than in men. SLE is mostly found in women of childbearing age, and pregnancy can induce or aggravate the disease. In addition, factors such as trauma, mental stress and overwork are also associated with the development of SLE. It is recommended that SLE patients should consult the rheumatology and immunology department of regular hospitals in time and follow the doctor’s instructions for standardized diagnosis and treatment.