There are several possible reasons for the stinging symptoms when applying the cream: 1. Some special healing creams, some of the active ingredients of which are in contact with the skin, will have a stinging or heating sensation. However, apart from the tingling sensation, the skin is in good condition, no damage, no rash, no local fever accompanied by painful symptoms, and the skin does not feel itchy, and after more than a week of treatment, there are no other abnormalities besides the tingling sensation, which is a normal drug action phenomenon. 2. Some patients with sensitive skin or skin diseases may experience tingling when applying the creams. 3.Some diseases may be slightly aggravated by the pain caused by the disease when applying the cream, or simply by the stinging pain caused by the injury or disease, and not caused by the cream.