Sore palms and weak grips can be caused by aseptic inflammation of the muscles or compression of the hand muscles leading to injury, etc. You can choose medication, physical therapy or rest to relieve the problem. 1. medication: when the hand muscle aseptic inflammation, will lead to palm pain grip weakness, you can choose non-steroidal anti-inflammatory drugs to alleviate the treatment, can eliminate the local aseptic inflammation, such as ibuprofen extended-release capsule, celecoxib capsules and other drugs to alleviate. 2. Physical therapy: patients with hand muscle compression leading to injury, there will be palm pain grip weakness symptoms, you can choose physical therapy to promote local blood circulation, accelerate the repair of damaged tissue, such as infrared therapy, microwave therapy. 3. Rest: When patients have palm pain and grip weakness, it is recommended that they take more rest to avoid secondary damage to the hand muscles caused by hand activities. When the patients appear palm pain grip weakness, it is recommended that patients go to the hospital in time for examination and diagnosis, and under the guidance of the doctor for medication to relieve.