Tubular adenoma with intraepithelial neoplasia of the colon with localized high grade suggests a high possibility of precancerous lesions, which requires regular follow-up colonoscopy or early surgical treatment. During colonoscopy, the examining doctor will take multiple pathological biopsies of suspected lesions based on what he/she sees under the microscope and his/her years of experience. If the pathological report suggests that colonic tubular adenoma with intraepithelial neoplasia is localized to a high level, which indicates that the tumor found in the intestine has the possibility of precancerous lesions, the patient will be advised to undergo resection as soon as possible to prevent cancerous lesions. Endoscopic resection is preferred, or surgical resection if this is not possible. If the pathology report is the result of biopsy after the patient’s surgical resection, then the patient should be advised to have a regular review, at least once every three to six months, and according to the result of the review to formulate the next step of the treatment plan, so as to avoid delaying the condition. Tubular adenoma of colon with intraepithelial neoplasia, localized to high level, is a kind of intestinal tumor pathology report results, it is recommended that the patient consult the relevant departments, listen to the professional doctor’s advice, formulate a reasonable and standardized treatment plan, to avoid delaying the condition.