Mycoplasma and Chlamydia are a pathogenic microorganism between bacteria and viruses, and there is a difference between these two pathogens. Mycoplasma is smaller and chlamydia is relatively larger. They belong to the same class of pathogenic microorganisms and can cause infections in the human urinary system, leading to diseases such as cystitis, urethritis and prostatitis; they can also cause diseases such as trachoma and pneumonia. The presence of pneumonia can lead to repeated high fever, coughing, coughing and asthma and other respiratory symptoms in humans. The two pathogens can be infected simultaneously or separately. The infection can be treated with macrolide antibiotics afterwards, with the preferred drugs being azithromycin and roxithromycin. Usually 2-3 courses of continuous treatment are needed to completely eliminate the microorganisms and improve the symptoms. Mycoplasma and Chlamydia infections are somewhat contagious during the disease, so attention needs to be paid to good patient isolation measures and thorough treatment to avoid recurrence.