Sourness and bitterness in the mouth may be caused by gastroesophageal reflux disease (GERD) or associated Helicobacter pylori infection, or it may be caused by heartburn syndrome, which is generally recommended to be treated with targeted medications. Some patients in the morning after waking up will appear in the mouth acidic and bitter phenomenon, the patient may be suffering from gastroesophageal reflux disease, it is recommended that the patient can do gastroscopy for diagnosis, the most commonly used drugs for the treatment of this disease is the proton pump inhibitor, can be used with omeprazole and lansoprazole. Patients may also have a combination of Helicobacter pylori, and patients can have a Helicobacter pylori test for diagnosis. Helicobacter pylori needs to be treated with a quadruple combination of drugs, such as lansoprazole, amoxicillin clavulanate, clarithromycin, and bismuth citrate potassium. Burning mouth syndrome is a neurogenic disorder of unknown etiology, and patients often suffer from psychological abnormalities such as anxiety and depression. The condition is characterized by dry mouth, burning sensation of the oral mucosa, and changes in taste. There is no effective clinical treatment, and antidepressants such as clonazepam and amitriptyline are usually required. Sour and bitter mouth need to actively seek medical attention to clarify the cause of the disease and then targeted treatment, the above drugs are recommended to be used according to medical advice.