Guidelines for the use of medication in hypertension should not consider what drugs lower blood pressure the fastest, but rather how to control blood pressure smoothly, and medications vary depending on the condition. Generally speaking, diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors, β-blockers, and angiotensin II receptor antagonists are all effective in controlling blood pressure. However, due to individual differences, a single medication may not be sufficient for smooth blood pressure control. For this reason, a combination of medications is needed. Combination of drugs is mainly used to control multifactorial disease-induced blood pressure instability, which often requires the combination of two or more antihypertensive drugs to achieve ideal blood pressure. Common combinations include calcium channel blockers + beta-blockers, beta-blockers plus diuretics, calcium channel blockers plus diuretics, etc., each of which is suitable for different types of patients. As each drug has certain contraindications and adverse effects, the use of drugs also needs to take into account the existence of individualized differences and cannot be generalized. The use and adjustment of antihypertensive drugs need to be carried out under the guidance of a doctor, and should not be taken blindly.