Rough and dry skin on the back of the hands may be related to dry skin, eczema, fungal infections and other conditions, and should be relieved through enhanced skin care and medication according to the cause. 1. Dry skin: You can apply hand cream or vitamin E ointment, urea ointment, etc. to keep your hands moisturized and relieve dry skin. 2. Eczema: If there is eczema on the back of the hands, there may be localized itching, rashes and oozing. You can follow the doctor’s instructions to apply glycerine lotion, dexamethasone acetate cream and other drugs to relieve itching, reduce repeated scratching, if necessary, with oral loratadine and other drugs. 3. Fungal infections: Fungal infections can lead to localized skin thickening, purple-red skin color, and itching. You can follow the doctor’s instructions to apply miconazole cream, ketoconazole cream and other drugs to relieve; severe lesions can also be combined with oral itraconazole, terbinafine and other drugs. It is recommended that patients consult a doctor in a timely manner to clarify the causes of rough and dry skin on the back of the hands, under the guidance of the doctor for treatment, do not self-medication.