Rheumatoid factor test results alone can not be used to determine the severity of the patient’s condition, but rather from the causes of rheumatoid, specific conditions and other aspects of a comprehensive analysis. Rheumatoid factor is a kind of autoantibody with denatured IgG as the target antigen, the normal reference range of this antibody is 0~20IU/mL, 250IU/mL has far exceeded the upper limit of the normal reference range, rheumatoid factor 250IU/mL is a positive result, which suggests that the patient may have autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Untreated rheumatoid arthritis patients have a positive rheumatoid factor test rate of about 80%, and patients with systemic lupus erythematosus, desiccation syndrome, scleroderma, etc., also have varying degrees of rheumatoid factor positivity, so patients with a rheumatoid factor of 250IU/mL need to further improve the relevant tests in order to make a definitive diagnosis. The severity of the patient’s condition can be analyzed according to the type of disease finally diagnosed, the progress of the disease and the presence of other complications. Rheumatoid factor test results need to be interpreted by a professional physician, it is recommended that patients go to the rheumatology and immunology department of a regular hospital for further consultation in order to avoid delaying their condition.