Berberine hydrochloride and domperidone are not recommended to be taken at the same time. Berberine Hydrochloride is an antibacterial drug that can treat enteritis and gastroenteritis caused by bacterial infections such as Shigella spp, hemolytic streptococcus, cholera, and Neisseria meningitidis. It can be used to relieve the symptoms of diarrhea, but may cause adverse reactions such as nausea, vomiting, and allergies. Domperidone is a drug that promotes gastrointestinal motility and can be used to treat dyspepsia, reflux esophagitis as well as nausea and vomiting. However, it may cause adverse reactions such as dry mouth, headache, drowsiness, allergy, and diarrhea. Because berberine hydrochloride is a drug for diarrhea and domperidone may cause diarrhea or aggravate the symptoms of diarrhea, the two are not recommended to be taken at the same time. Therefore, the medication must be taken under the guidance of a doctor, and it is not recommended to take the medication on your own.