Pain in the inner thigh root due to friction may be due to an impregnation reaction in the area and a break in the epidermis due to friction. Firstly, the original skin that has been abraded needs to be protected and can be temporarily applied topically with rehabilitative new liquid, which can promote the production of epidermis and improve the local inflammatory reaction to the maximum extent. Secondly, if significant erosions form in the area, topical application of zinc oxide oil can be used, which can also promote the relief of local erosions and exudative reactions. If the patient’s pain in the area is also accompanied by some infection, such as the appearance of secondary bacterial infection, anti-inflammatory and anti-infective treatment is also required, such as oral roxithromycin or cefadroxil.