Cirrhosis of the liver alpha-fetoprotein gradually increased to 780ug / L, the resection of the tissue test is benign is the reason may be other lesions caused by alpha-fetoprotein elevation. Alpha-fetoprotein is a glycoprotein, mainly synthesized by fetal hepatocytes and yolk sacs, which can be used to help diagnose primary liver cancer and can monitor the efficacy of primary liver cancer, but it is a reference indicator, not an absolute indicator. Benign diseases such as acute and chronic hepatitis and cirrhosis can also increase alpha-fetoprotein, but most of them are less than 1000ug/L, and the increase is usually transient, usually lasting less than 3 weeks. It is not only when the liver has disease that the alpha-fetoprotein is elevated, in childhood liver cancer, hepatoblastoma, gonadal teratoblastoma, hepatitis and so on will make it increase; adult testicular cancer, ovarian tumor, malignant teratoma, pancreatic cancer, gastric cancer, intestinal cancer, lung cancer and so on can also be increased. Alpha-fetoprotein can be used as a reference, and the gold standard for diagnosis is pathology test.