Amlodipine benzenesulfonate belongs to the first-line antihypertensive drugs of calcium channel blockers, with a wide range of action, suitable for the prevention and treatment of hypertension and unstable angina, and can be taken for a long time. For patients with chronic renal insufficiency, it is not recommended to take a large amount of the drug for life, because it will cause mild damage to liver and kidney function, especially when taking the above drug for three months to more than half a year, there will be varying degrees of mild hepatic and renal function impairment. Therefore, it is recommended to review the liver function and kidney function after taking the above drugs for about one month, especially referring to the reference values of alachlor aminotransferase, alanine aminotransferase, blood creatinine and blood urea nitrogen, and stop taking amlodipine phenylsulfonate once there is an increase in the indicators. The adverse stimulation of hepatic and renal function can be improved by choosing drugs of the ACEI class or ARB class for drug replacement.