The causes of hard lumps in the chest that hurt when pressed are more common in the clinic, such as breast cancer, breast hyperplasia, breast fibroma and other mammary diseases, and may also be due to boils, sebaceous cysts and other surface swellings, which need to be treated with general treatment, medication and surgery according to the specific causes. 1. Breast cancer: Breast cancer may appear as a hard lump in the chest with pain. It requires complete examination to clarify its stage and typology, and according to the condition, surgical treatments such as radical mastectomy can be given, as well as other therapies such as radiation therapy and chemotherapy (doxorubicin, etc.) can also be given. 2. Breast hyperplasia: Breast hyperplasia can lead to hard lumps and pain in the chest, and the treatment requires regular diet and lifestyle, not staying up late, etc. If necessary, medication can be given, such as tamoxifen and so on. 3. Breast fibroid: benign tumors, occasionally painful symptoms, drug treatment is ineffective. Clinical treatment is mainly surgical, such as mastectomy for breast fibroma. 4. Boils: Bacterial infection of hair follicles and surrounding tissues, mild cases can be treated with antibacterial drugs such as amoxicillin, and larger abscesses can be treated with surgical incision and drainage. 5. Sebaceous cysts: most of them are painless, but when accompanied by bacterial infection, they can be painful and even pus-filled. For mild cases, cephalosporins and other drugs can be given for anti-infection treatment, and for abscess formation, surgery can be given for incision and drainage. The specific situation is recommended to go to the hospital, improve the examination, clear the cause of the disease, drugs need to be used under the guidance of a professional physician.