Creatinine is a product of muscle metabolism in the body and is mainly present in the blood. Creatinine mainly comes from the amount of meat consumed and its own muscle content, and the amount of creatinine metabolized by the organism every day is relatively constant. Low creatinine may occur due to a variety of reasons, such as diet, medication and disease, etc.: 1, the cause of symptoms: 1, dietary factors: due to long-term malnutrition, the intake of various nutrients less, resulting in muscle malnutrition; can also be due to long-term fasting meat, resulting in protein intake caused by insufficient body wasting, can lead to low blood creatinine; 2, disease factors: common in anemia, leukemia, thyroid The disease itself leads to excessive metabolism of blood creatinine, and some diseases require long-term bed rest, resulting in lower muscle content, thus causing low blood creatinine; 3, drug factors: some patients taking drugs may lead to low creatinine, such as kidney disease long-term use of uremic pellets, kidney failure, etc., creatinine will appear to reduce the phenomenon; 4, other: the elderly, pregnant women, etc. due to less exercise. Pregnant women, etc. due to less exercise, resulting in a decrease in muscle content, which leads to less metabolites in the muscle. Second, the response: 1, diet: a high-protein diet, pay attention to balanced nutrition, appropriate intake of eggs, soy products, meat, etc., to supplement muscle content, can make muscle metabolism normal production. Patients with anemia can eat more food such as jujube and cinnamon, as well as animal offal, which have a certain effect on replenishing blood cells; 2. Exercise: the elderly can exercise appropriately according to their personal conditions, including walking, tai chi, etc., to enhance their muscle content and resistance. Pregnant women should not rest too much, and appropriate activities are also beneficial to the development of the fetus; 3, life: pay attention to rationalization of rest, avoid overwork, which can cause other diseases; more sun exposure, calcium supplementation, to enhance physical fitness; 4, treatment: the need for treatment of the original disease, such as anemia can be given appropriate iron supplements, hyperthyroidism oral propylthiouracil, methiodine, etc.