Down’s syndrome is a chromosomal syndrome that is common at this stage of life. The child has a range of serious clinical symptoms, including mental retardation and lack of fertility. The risk of having a child with Down’s syndrome is generally higher with age. The older a woman is, the more likely she is to have an abnormal splitting of the egg during the formation of the fertilized egg, which can lead to chromosomal abnormalities in the embryo, so for women who are pregnant after the age of 35, genetic counseling and prenatal diagnosis must be done regularly. Prenatal diagnostic methods are invasive and have a certain rate of miscarriage, infection, and water breakage, but they can check the morphology and number of all 23 pairs of chromosomes, which is why they are called prenatal diagnostic methods. If an advanced pregnant woman has concerns about prenatal diagnosis, requests a prenatal screening method or refuses to undergo prenatal diagnosis, it is important to have adequate genetic counseling to understand the pros, cons and limitations of screening and diagnostic methods and make a decision. Any woman can be pregnant with a child with Down’s syndrome, so it is important to strictly follow the time of prenatal screening, which can be done by doing Down’s syndrome screening, systematic screening ultrasound and other screening methods, and if found to be a Down’s syndrome child need to promptly undergo genetic counseling to decide whether to terminate the pregnancy in time.