There are many factors that cause hiccups, such as physiological factors such as eating too fast and pathological factors such as reflux esophagitis. 1. Physiological factors: eating too fast, eating too much, eating spicy and stimulating, raw and cold or too hot food, drinking too much alcohol or carbonated beverages, etc., can cause hiccups, but usually in a short period of time can disappear on their own. 2. Pathologic factors: (1) digestive tract diseases: such as reflux esophagitis, intestinal obstruction, cholecystitis, gastric ulcer, etc., can trigger hiccups. It can be accompanied by nausea, acid reflux, abdominal pain, abdominal distension and other manifestations. (2) Lung diseases: pneumonia, lung cancer, pleurisy, etc. Patients may also be accompanied by chest pain, dyspnea, cough, hemoptysis and other symptoms. (3) Mediastinal diseases: myocardial infarction, pericarditis, etc., in addition to hiccups, there are chest pain, shortness of breath, palpitations and other manifestations. (4) Central nervous system diseases: cerebrovascular lesions, encephalitis, meningoencephalitis, craniocerebral injury, etc., often accompanied by headache, impaired consciousness and other symptoms. There are many other causes of hiccups, it is recommended to seek timely medical treatment to identify the cause of the disease and then targeted treatment.