There is no fastest way to treat pediatric hand, foot and mouth disease, hand, foot and mouth disease is an infectious disease caused by enterovirus, there is a lack of effective therapeutic drugs, the main treatment is general treatment, drug treatment. 1. General treatment: Hand, foot and mouth disease can be transmitted through respiratory droplets and contact, children with hand, foot and mouth disease should be isolated and treated in a timely manner to avoid cross-infection; attention should be paid to the protection of the child’s skin, to avoid scratching; may be appropriate to drink plenty of water, to maintain adequate rest, and to keep the indoor air fresh. 2. Medication: If the fever of the child exceeds 38.5℃, acetaminophen, ibuprofen and other antipyretic and analgesic medications can be used to treat the fever, and physical cooling can be supplemented at the same time. Generally do not need special application of antiviral drugs. For more severe cases, glucocorticosteroids such as methylprednisolone and gammaglobulin may be prescribed to control symptoms. Children with HFMD should go to the hospital in time and follow the doctor’s instructions for active treatment to avoid delay. All of the above medications should be used under medical supervision.