White peony for buttercup plant peony dried root, the ancestral medicine that it has nourishing blood and softening the liver, slow in the pain and astringent Yin to collect sweat effect, is one of the important formula in the treatment of a variety of diseases, widely valued by the pharmaceutical industry. The active ingredients of Paeonia lactiflora are mainly a group of glycosides, including paeoniflorin, hydroxyl paeoniflorin, paeoniflorin, paeonolactone glycosides and benzoyl paeoniflorin, collectively known as total paeoniflorin (TGP), of which paeoniflorin accounts for more than 90% and is the main active ingredient of Paeonia lactiflora. The pharmacology and clinical research of TGP found that it can inhibit autoimmune reaction in multiple ways, has anti-inflammatory, analgesic and hepatoprotective effects, and has good application prospects for the treatment of rheumatic immune diseases. The efficacy of TGP in patients with RA has been studied for a long time. TGP is not only similar to methotrexate, but also has a high safety profile and is better tolerated than low-dose methotrexate. A multicenter, randomized, open-label, controlled study in China included 370 patients treated for 24 to 48 weeks. The results showed that the efficacy of TGP alone or in combination with methotrexate and salbutamol was comparable to the established efficacy of methotrexate alone and methotrexate in combination with salbutamol, and that TGP is a more effective and safe phytotherapy for the relief of RA. Recently, with the changing concept of RA treatment, the use of TGP in combination with other disease-modifying drugs (DMARDs) has been increasing, whether TGP + methotrexate, TGP + methotrexate + lorazepam, TGP + raltegravir or TGP + leflunomide. The dose and adverse effects of other DMARDs or NSAIDs can be reduced, and patient compliance can be increased. 2. Systemic lupus erythematosus (SLE) TGP has also shown some advantages for the treatment of SLE. A study showed that the overall efficiency of the TGP group was significantly higher than that of the placebo group, and the glucocorticoid dosage was significantly reduced compared with that before treatment. The efficacy of TGP in patients with lupus nephritis was reported. The results of treatment with TGP + moderate or low dose glucocorticoids showed that SLE activity was controlled, urine protein was reduced, renal function was normalized, anti-nuclear antibody and anti-double-stranded DNA antibody titers decreased, and lupus cells turned negative, suggesting that TGP is effective in lupus nephritis. 3, ankylosing spondylitis (AS) TGP combined with other drugs for AS can enhance the efficacy and reduce adverse effects. Some scholars used TGP + methotrexate, SASP and methotrexate + lutetrapyridine to treat AS, and found that the efficacy of the treatment group with TGP was significantly better than that of the control group, and the adverse effects were significantly reduced. In another report, TGP was used to treat patients with undifferentiated spondyloarthropathy and was found to be effective in relieving joint swelling and pressure, resting pain, and improving joint function with minimal adverse effects. Further studies suggest that its mechanism of action is related to the reduction of IL-1 and TNF-α levels in the body and the regulation of the body’s immune function. 4.Dry Syndrome (SS) TGP is effective and safe in treating SS. It can improve the symptoms of dry mouth and reduce blood sedimentation, and can be used for a long time. A controlled study of TGP and hydroxychloroquine sulfate showed that the efficacy of TGP in treating SS is comparable to that of hydroxychloroquine sulfate, with an onset of action of 6 to 12 months and a better safety profile than hydroxychloroquine sulfate. TGP has a therapeutic effect on immune-related liver disease, which provides a new therapeutic idea for the treatment of autoimmune hepatitis with TGP. The main adverse effects of TGP are gastrointestinal symptoms, such as mild abdominal pain, poor appetite, diarrhea and change in stool pattern, which usually do not require treatment and may resolve on their own after discontinuation. In summary, TGP affects cellular immunity, humoral immunity and inflammatory processes in several aspects, and has immunomodulatory, anti-inflammatory and analgesic effects as well as hepatoprotective and vascular endothelial cell-protective effects. It is believed that with the development of more basic and clinical research, TGP will have a broader clinical application prospect.