Pepsinogen II is synthesized and secreted by the cells of gastric fundus gland, cardia gland and pyloric gland, which can reflect the secretion function of gastric mucosa. The reason of low pepsinogen II may be the lesion of gastric fundus mucosa, such as acute and chronic gastritis, gastric ulcer, etc. You can go to the hospital to do gastroscopy, or take biopsy of the pathological tissues under gastroscope, which can get the exact diagnosis, and you can give dietary modification and medication to regulate. 1. Dietary management: patients should pay attention to the diet regular light in daily life, avoid spicy greasy stimulating food, eat more vegetables and fruits, drink more water, and avoid staying up late. 2. Drug regulation: if there is damage to the gastric mucosa, you can take oral gastric mucosa protector and acid inhibiting drugs, such as bismuth potassium citrate, cimetidine, omeprazole treatment, and oral polypeptide tablets to replenish the body’s endocrine deficiencies. Low pepsinogen II should go to the hospital in time, under the guidance of the doctor’s treatment, and regular review.