Side effects of chemotherapy for squamous cell carcinoma mainly include gastrointestinal reaction, liver function impairment, bone marrow suppression, renal function impairment, cardiac impairment, hair loss and so on. 1. Gastrointestinal reaction. Gastrointestinal reaction is one of the most common side effects of chemotherapy for squamous cell carcinoma, and patients may have a series of gastrointestinal reactions such as abdominal distension, abdominal pain, nausea, vomiting, constipation and so on. 2. Bone marrow suppression. Chemotherapeutic drugs may affect the blood system, resulting in the reduction of the number of red blood cells, platelets, white blood cells and so on, which is called bone marrow suppression. 3. Liver function damage. Chemotherapeutic drugs may cause liver function damage, mainly manifested by the increase of glutamic oxaloacetic aminotransferase and glutamic alanine aminotransferase, which may be accompanied by the increase of serum bilirubin, and may even progress to liver failure. 4. Renal function damage. Renal function damage is mainly manifested in the increase of creatinine and other values. 5. Heart damage, chemotherapy drugs may affect the cardiomyocytes and cardiac conduction system. 6. Hair loss. Hair loss is one of the common side effects of chemotherapy. It usually improves after chemotherapy is stopped. After squamous cell carcinoma patients have chemotherapy side effects, they should inform their doctors in time and choose appropriate ways to relieve them.