The causes of most rheumatic diseases are still unclear, but they are generally related to genetic factors, environmental factors and infectious factors. 1. Genetic factors: most rheumatic diseases, such as ankylosing spondylitis, rheumatoid arthritis, systemic lupus erythematosus, etc., have a certain family genetic susceptibility. 2. Environmental factors: Some rheumatic diseases, such as systemic lupus erythematosus, may be triggered by long-term exposure to ultraviolet rays or exposure to chemicals and other environmental factors. 3. Infectious factors: A variety of infectious agents such as streptococcus can directly or indirectly stimulate the immune response, thus leading to the development of rheumatic diseases. The occurrence of rheumatic diseases may also be related to other factors, and there are differences in the causes of different rheumatic diseases, it is recommended to go to the hospital in a timely manner, and cooperate with doctors to standardize the diagnosis and treatment.