Whether SLE requires lifelong medication needs to be decided by the doctor according to the condition, and clinically it usually requires long-term or even lifelong medication to maintain the treatment. SLE is a systemic autoimmune disease caused by genetics, infection, sex hormones and other factors. It can involve multiple systems and organs throughout the body. The disease is prone to recurrence, manifested by mental changes, annular erythema, anemia and other symptoms. There is no cure for SLE. Some people with SLE need to take small doses of glucocorticosteroids such as prednisone for maintenance treatment, while some people need to take immunosuppressants such as cyclophosphamide and tacrolimus for treatment. The medications are taken to control the disease and avoid organ damage. Therefore, during the period of taking medication, you need to consult your doctor regularly, and the doctor will decide the duration of medication according to the recovery of your condition and the tolerance of the medication. In clinical practice, long-term or even lifelong medication is usually needed to control the progression of the disease. It is recommended that SLE patients should consult the rheumatology department in time and receive standardized treatment under the guidance of doctors.