Children’s fever hands and feet are very hot, need to reasonable fever symptomatic treatment, at the same time need to clarify the causes of fever for the cause of treatment, such as influenza children need oral oseltamivir phosphate. 1. Symptomatic treatment: fever is a common symptom of pediatric diseases, when the body temperature rises and accompanied by very hot hands and feet, this time need to be appropriate to reduce clothing, the use of lukewarm water to wipe, increase the heat to make the body temperature drop, and monitor the temperature, such as the temperature exceeds 38.5 ℃ need to use antipyretic drugs (such as ibuprofen or acetaminophen) for symptomatic antipyretic. 2. Treatment of the cause: need to identify the cause of fever, and intervention, such as infectious diseases, the above phenomenon can be seen in children with influenza, the need for oral treatment of oseltamivir phosphate. In acute upper respiratory tract infections caused by bacterial infections, anti-infective treatment with antimicrobial drugs (e.g., cefaclor) is required. In non-infectious diseases, such as acute leukemia, the above phenomenon can also occur, after the diagnosis of such children, need to use vincristine and other drugs for chemotherapy or hematopoietic stem cell transplantation and other treatments. There are many reasons why children’s hands and feet are hot with fever, so it is recommended to consult a doctor in time and have the treatment guided by a specialist. The use of medication should follow the doctor’s instructions.