Abnormalities of the lymphatic system can be manifested as localized lymph node enlargement and tenderness, which can be caused by infection or lymph node metastasis from the primary focus, and can also be seen in hematological disorders such as non-Hodgkin’s lymphoma, and immune system disorders, for which anti-infective treatment and treatment of the primary disease can be provided. 1. Caused by infection: mostly due to bacterial or viral infection, causing immune system reaction and local lymph node enlargement or pressure pain. Bacterial infection can be treated with antibiotics, such as cefadroxil tablets, erythromycin dispersible tablets. In case of viral infection, antiviral treatment can be given with ribavirin tablets. 2. Lymph node metastasis from primary foci: mostly seen in malignant tumors, at this time, we should start from the treatment of primary foci, consider surgical resection of the primary foci, and clear the surrounding lymph nodes, in order to reduce the systemic lymph node involvement. 3. Hematologic diseases: such as non-Hodgkin’s lymphoma, etc., cyclophosphamide, vinblastine and other drugs can be used for chemotherapy. 4. Immune system diseases: such as systemic lupus erythematosus, which can be treated with drugs such as prednisone. Abnormalities in the lymphatic system may also be caused by leukemia, etc. It is recommended to consult a doctor in time when discomfort occurs, and choose medication under the doctor’s guidance, rather than self-medication.