Gastric cancer is a common malignant tumor in the digestive system. Gastric cancer can reach the skull and brain through hematogenous metastasis, and once brain metastasis occurs, it means that the disease has reached an advanced stage and lost the chance of radical surgery. For multiple brain metastases treated with whole brain radiotherapy or partial brain irradiation, additional treatment with dehydration and hormone therapy is needed to reduce intracranial hypertension and improve symptoms such as headache and dizziness. Some patients also need to apply chemotherapy combined with targeted therapy to fight against tumors. Currently, the commonly used chemotherapy regimens include docetaxel combined with oxaliplatin and tegeo, tegeo and oxaliplatin combined with Herceptin for treatment, tegeo plus oxaliplatin plus apatinib for treatment or apatinib alone for treatment, etc.