Adults who have a bad cough can be due to tuberculosis, lung cancer, lung infections, allergies and other causes, and need to improve the relevant examinations to determine the cause of the disease, and then be targeted treatment. 1. Tuberculosis: If the cough is accompanied by low fever in the afternoon, night sweats, fatigue or occasional coughing up blood, chest CT, T-cell test for tuberculosis infection and other relevant examinations should be perfected. After clear diagnosis, anti-tuberculosis treatment should be given, and commonly used drugs include isoniazid and rifampicin. Lung cancer: If there are symptoms such as chest pain and blood in sputum, chest CT, tumor marker examination should be perfected, or the lesion site can be observed directly under bronchoscopy, and tissues should be taken and sent for examination if necessary. After clear diagnosis, surgical treatment such as segmental lung resection, chemotherapy such as pemetrexed, targeted drug therapy such as bevacizumab can be given. 3. Lung infection: If there are symptoms such as high fever, coughing up pus and sputum, most of them are considered to be caused by lung infection. Chest CT, blood test, C-reactive protein and sputum culture should be perfected in order to determine the pathogens of lung infection, and then sensitive drugs such as cefixime or azithromycin should be given. 4. Allergic cough: a number of cough without sputum, manifested as irritating cough, mostly consider allergies, can improve the allergen examination, actively search for allergens, and improve the surrounding environment, if necessary, under the guidance of the doctor to use medication such as chlordiazepoxide, cetirizine and so on. Adults cough has been bad, there may be other reasons, such as postnasal drip syndrome, gastroesophageal reflux disease, etc., should be timely to the hospital and do the relevant auxiliary examination, in order to determine the cause of the disease, to give targeted treatment, the use of medication need to follow the doctor’s instructions.