Supplemental Jiale, or estradiol valerate tablets, can be taken by men appropriately if there is a clear indication. Estradiol valerate tablets can supplement estrogen and are mainly used for diseases caused by estrogen deficiency, such as hot flashes and night sweats, urinary incontinence, neurasthenia, sleep disorders, vulvovaginal atrophy in females, difficulty in sexual intercourse, and bone loss caused by estrogen deficiency. Common adverse reactions to estradiol valerate are breast tenderness, stomach upset, nausea, and headache. It is contraindicated in pregnant and breastfeeding women, breast cancer patients, patients with severe liver disease and vascular embolism. Men who have high sex hormones can take estradiol valerate in moderation under doctor’s supervision. However, excessive use of estradiol valerate will lead to slow atrophy of genitals, feminized manifestations such as breast development, lack of laryngeal nodes, thinning of voice, etc. In serious cases, it will also lead to sexual dysfunction such as impotence, affecting fertility. If men need to be treated with Estradiol Valerate due to their condition, they need to be under the guidance of a professional doctor and strictly grasp the indications, please do not take it on your own.