In neurosurgery, craniocerebral injury is one of the most common disorders. In general, according to the anatomical part of the skull, it is categorized as scalp injury, skull injury and brain injury, and two or three of them may exist in combination. A question was asked about a soft tissue density shadow in a 6-year-old skull with an area of perforation-like bone defect. The statement in this question is generally an imaging description that initially suggests that a skull injury and brain injury may be involved. In this case, the area of puncture-like bone defect may be the result of damage to the skull caused by an external sharp object during trauma, or it may be the skull defect left after removal of the bone flap by cranio-cerebral surgery; whereas the soft tissue density shadow may be the result of an infarction, a hematoma, an inflammation, a tumor, or calcification of the tissues, which requires further examination, combined with the clinical diagnosis, and then precise treatment. After the soft tissue density shadow problem is solved by treatment, cranial bone repair should be carried out in time, because long-term cranial bone defect will have a great impact on the health and growth of the child. In cranial repair, it is very important to choose a high-quality hospital, excellent experts and excellent materials. At present, the widely used cranial bone repair material is titanium alloy mesh, but this traditional titanium mesh material in fact there are some defects and shortcomings, such as the use of titanium mesh material for cranial bone repair, some patients may have postoperative infections, wear and tear of the scalp, skin ulceration, material exposure, collapse and deformation, in addition, due to the strong thermal conductivity of the metal material, the patient may be sensitive to the external environment of the external cold and hot discomfort, and may also affect the patient to receive CT MRI. In addition, due to the strong thermal conductivity of metal materials, patients may be sensitive to external hot and cold environments after surgery, which may also affect the patients to receive CT MRI and other medical examinations. At present, there is a new type of polyether ether ketone PEEK material, which is a special polymer material, excellent performance, very good to overcome the above problems of titanium mesh, and PEEK material can be personalized according to the patient’s cranial data for three-dimensional shaping, highly restored cranial structure, aesthetic beauty of good. In addition to the repair material, the surgical technique is also very important. At present, our team not only use the excellent performance of polyether ether ketone PEEK material, but also continue to improve the technology and material optimization and upgrading, and innovative introduction of the concept of cosmetic plastic surgery, while the comprehensive implementation of the PEEK cranial repair plastic surgery, can be achieved a good repair effect, to achieve anatomical restoration, functional perfection, beautiful organic unity of the appearance. At the same time, the hospital’s strong strength of the Divine Surgery Center, for cranial defects combined with a variety of other difficult intracranial diseases can be solved together, many patients get good treatment, praise.