High CA19-9 and CA242 means that the doctor’s attention should be drawn to the CA19-9 and CA242 if only a slight increase, this does not necessarily mean that there is any disease or lesion, in this case, regular checkups can be. If CA19-9 and CA242 are both significantly elevated, we should further look for the cause. CA19-9 may indicate the possibility of pancreatic cancer, and CA242 mainly indicates tumors in the digestive tract, in which case we should further do imaging tests, including CT and endoscopy, such as gastroscopy and enteroscopy, etc., and if abnormalities are found, we should take the pathology to be able to confirm the diagnosis.