The main consideration is that anal fissure caused by sentinel hemorrhoids or anal papilloma, but also does not rule out boils, perianal abscesses, rectal polyps, rectal cancer and other diseases caused by. 1. Sentinel hemorrhoids: long-term anal fissure can cause spasm of the internal anal sphincter, resulting in local tissue proliferation, local skin superficial venous reflux obstruction caused by edema, then the formation of sentinel hemorrhoids, manifested in the anus as a symptom of a long meatball. 2. Anal papilloma: belonging to one of the anal fissure comorbidities, long-term inflammatory stimulation can be secondary to the generation of anal papilloma, manifested in the anus at the long ball of meat, the volume increases can cause blood in the stool, pain, anal swelling and other uncomfortable symptoms. 3. Boils: local skin follicle bacterial infection in the anus, can form local follicular papules, gradually develop into hard nodules, can be manifested as the symptoms of anus at the long ball of flesh, accompanied by redness, swelling, pain and other symptoms. 4. Perianal abscess: perianal abscess breakout may cause anal fistula, anal fistula outside the mouth of the ulcerated skin papillary proliferation, can be manifested as meatball. 5. Rectal polyps: mostly associated with heredity, intestinal inflammation, bowel habits and other factors. Rectal polyps with longer tips may prolapse from the anus and show the symptom of localized meatball in the anus. 6. Tumor: such as rectal cancer can cause abnormal proliferation of rectal epithelial cells, if the lesion is large, it may be detached from the anus, thus manifesting the symptoms of local meatballs, accompanied by blood in the stool, changes in bowel habits, body weight loss and other symptoms. It is recommended that people with anal fissure who have long meatballs for many years go to the hospital in time to find out the reason for the long meatballs in the anus, and actively treat them so as not to delay the condition.