After staying up late and not being able to sleep, it is often due to the fact that the patient’s normal sleep rhythm is disturbed after staying up late, resulting in the patient having difficulty falling asleep. In this case, it is recommended that patients adjust their sleep as soon as possible, it is recommended that they go to bed on time, get up on time, stay in bed for no more than 8 hours at night, go to bed before 11:00 p.m. It is recommended that they try not to take a lunch break during the day, stay out of bed during the day as much as possible, and increase the number of exercises during the day. If you have acute insomnia after staying up late, you can also consider applying short-acting drugs that help you fall asleep and have few side effects, such as zolpidem tartrate or dexzopiclone, or melatonin receptor agonists, which are available in China, and can be adjusted in time, so that you can take them as needed when your sleep rhythm is adjusted, and gradually reduce the dosage and stop the medication gradually.