Wheezing and dyspnea at night may be due to asthma attack, heart failure, obstructive sleep apnea hypoventilation syndrome, etc., and medication is needed for the cause. 1. Asthma attack: due to the increase of vagal tone at night, it is easy to have vagal excitation and lead to bronchoconstriction spasm and asthma attack, so it is more likely to have wheezing and dyspnea at night. Treatment can be applied to relieve the symptoms by inhalation therapy with drugs such as albuterol, terbutaline and budesonide. 2. Heart failure: due to the abnormal contractile function of the left ventricle, resulting in decreased ejection fraction of the heart, the pulmonary circulation is stagnant, and the increase in the volume of return blood lying down at night further increases the burden on the heart, so there are symptoms such as wheezing at night, dyspnea and so on. Treatment can apply furosemide, metoprolol, isosorbide nitrate, digoxin and other drugs. 3. Obstructive sleep apnea hypoventilation syndrome: due to the upper airway anatomical abnormality, obesity and other factors lead to ventilation disorder during sleep, snoring, apnea, suffocating, gasping, dyspnea and other symptoms. Treatment actively corrects the cause of the disease, such as anatomical narrowing of the nose and pharynx can be surgically treated, or non-invasive positive airway pressure ventilation therapy can be used to improve the symptoms. The breathlessness and dyspnea at night can also be caused by other diseases, it is recommended to consult the doctor in time, improve the examination, clarify the cause of the disease, and follow the doctor’s instructions for treatment.