Montelukast can be used for the treatment of acute and chronic diarrhea, contraindications include patients who are allergic to the drug. Montelukast is a kind of antidiarrheal drug, can form a protective film in the intestinal tract, and montelukast has strong adsorption ability to the gastrointestinal mucosa, can improve the mucosal barrier to the defense ability of the attack factor, so it is often used in the acute and chronic diarrhea of adults and children’s symptomatic treatment. Contraindications to montelukast include hypersensitivity to any of the components of the drug (the main component is montelukast, dressings include sodium saccharin, vanillin, etc.). Mild constipation may occur in a few patients after the use of the drug. Patients who need to use montelukast for treatment should use the drug under the supervision of a doctor.