Acupuncture has the effect of unblocking meridians and regulating qi and blood, which can theoretically treat many diseases, but in practice has little effect on some diseases. In order to meet the needs of acupuncture clinical treatment and research development, the World Health Organization meeting in Milan, Italy, held in November 1996, proposed 64 indications for acupuncture, and the following discussion: (1) the use of similar acupuncture method or traditional therapy randomized controlled trial of acupuncture indications are: alcohol withdrawal, allergic rhinitis (hay fever), athletic syndrome, facial paralysis, biliary colic, bronchial asthma, cardiac neurosis, cervical spondylosis, chronic pain of the motor system (neck, shoulder, spine, knee, etc.), depression, detoxification, dysmenorrhea, headache, hemiplegia or other sequelae of encephalopathy, herpes zoster, hypertension, voluntary hypotension, impotence, induced labor, insomnia, leukopenia, lumbago, migraine, pregnancy reaction, nausea and vomiting, frozen shoulder, post-surgical pain, premenstrual tension, nerve root pain syndrome, renal colic, rheumatoid arthritis, sprains and strains, jaw joint dysfunction, tension headache, smoking cessation, trigeminal neuralgia, urinary tract stones. (2) Indications for acupuncture with a sufficient number of patients as a sample but without randomized controlled trials are: acute tonsillitis and acute pharyngitis, back pain, biliary ascariasis, chronic pharyngitis, fetal malposition, pediatric enuresis, tennis elbow, gallstones, irritable bowel syndrome, Meniere’s disease, myofasciitis, childhood myopia, simple obesity, post-tonsillectomy pain, schizophrenia, and sciatica. (3) Acupuncture indications with repeated clinical reports, faster results or some trial basis are: constipation, breast deficiency, diarrhea, female infertility, gastroptosis, eruption, urinary incontinence, male infertility (lack of sperm, lack of sperm motility), painless delivery, urinary retention, sinusitis. In summary, combined with clinical experience, indications for which acupuncture is significantly more effective than drugs include acute sprains, lumbar synostosis, cervical spondylosis, frozen shoulder, chronic soft tissue injuries (including tennis elbow and myofasciitis), facial palsy, post-stroke sequelae, herpes zoster, migraine, insomnia, simple obesity, eruption, and jaw joint dysfunction.