Systemic lupus erythematosus is a type of rheumatic disease and is considered a very serious disease. In this disease, there are symptoms from head to toe, hair loss, facial butterfly erythema, mouth ulcers, arthritis, myositis, pneumonia, pleurisy, neuropsychiatric symptoms, enteritis, peritonitis, nephritis, hepatitis, hemocytopenia ……. What is this all about? What disease can be so powerful that it involves almost all organs of the body. In fact, lupus is only a typical rheumatic disease, so see so much damage, in fact, other rheumatic diseases, including rheumatoid arthritis familiar to the people as well can widely involved in multiple organs throughout the body, just most cases to joint damage, the involvement of other organs are generally not examined in detail, it is difficult to be noticed. Rheumatic disease is a civil war that takes place inside the body. We have a perennial high alert garrison in our body, the white blood cells, which are responsible for detecting foreign enemies, removing dead cells from the body, monitoring cells that become abnormal and destroying them. The same functions are performed by the police force. However, now there is a large-scale war, which can be external (external enemy invasion) or internal (internal mismanagement), resulting in a war within the police force, with the consequence of smoke everywhere and wreckage everywhere. Where there was an enemy, there was shelling and damage. The places where there was no enemy were also bombed by mistake by the frightened armed forces. As a result, what was originally a local war evolved into a full-scale war, and the wounded, in addition to the armed personnel (white cells), involved almost all units, whether they were central organs (brain, nervous system), factories (liver), functional units (muscles and joints responsible for movement, kidneys responsible for water circulation processing, skin responsible for protecting the organism mucous membranes), etc. The cure is to stop the civil war and make peace. The prerequisite for peace talks is to lay down the arms. Immunosuppressants such as hormones and immunomodulators play this role, first put down the gun. The body’s immune system functions mainly by the gun, without the gun, the immune system is at rest. The disadvantage is that after the discovery of the real external enemy invasion can only rely on close combat, so the power to resist external aggression is weaker, the ability to find and destroy the internal thieves is weaker, the ability to find and destroy the internal tumor cells is reduced. Therefore, after putting down the weapons, let everyone “calm down” for a while, and then gradually withdraw the immunosuppressive drugs, so that the body’s immune system can basically play its normal function of defending the country. However, peace is not easy to obtain, the result of civil war is that both sides lose, and after we use drugs to control the army’s weapons, the foreign enemy will take advantage of the situation at any time. Since the weapons are removed and there is no ability to resist for a while, it is common for patients who have been taking hormones for a long time to get infections, viruses (shingles, CMV, etc.), bacteria and other infections, leading to pneumonia, skin infections, etc. After antibiotic treatment, they are temporarily well, but long term peace cannot always rely on foreign aid. The decrease in the activity of the immune system in our own body, which cannot perform its duties, will inevitably lead to repeated infections and Multiple infections. Moreover, at any time, it may cause the internal forces to lose control and take up arms again to fight back, which will not only scare away the enemy, but also trigger a new round of arms race and another civil war. Patients will be hospitalized again, hormones will have to be increased, and even more violent treatment will be required, cyclophosphamide shocks, strengthening dragon shocks, and even the addition of cytotoxic drugs with greater side effects. With each full-blown civil war, the people are hit hard. There is always a time when the civil war cannot be quelled, the external enemy continues to invade, and the warlords in the body are divided (tumors arise), which eventually leads to the patient’s inability to support, heart failure, kidney failure, respiratory failure, and towards the end of life. Therefore, the control of this war requires experience, using drugs to force soldiers to put down their weapons, which has a lot of learning, the power is too weak, the soldiers weapons can not be unloaded, the power is too strong, the consequences are endless. The good thing is that, over the years, doctors have accumulated a wealth of experience in dealing with complex situations, and so far, the vast majority of patients have good long-term health status. However, patients need to actively cooperate and listen to their doctors’ instructions. Modern medicine is developing at a rapid pace, new biological agents are emerging, and more effective drugs are believed to appear soon in the near future. The active position of human beings in this war will become stronger and stronger. In the days when there were no hormones, lupus was almost incurable; nowadays, lupus patients can basically live and work like normal people. We believe the future will be better.