The difference between the skin changes caused by syphilis and the symptoms of folliculitis includes the morphology as well as the time of onset, among other things. However, syphilis may be combined with folliculitis, so laboratory tests are also needed to differentiate. 1. Morphology: (1)The skin changes caused by syphilis are mainly manifested as flaky erythema, which can also be manifested as maculopapular rash, blisters, pustules and so on, and the erythema can be necrotic and form painless ulcers. (2) The symptoms of folliculitis are mainly manifested as small pustular papules protruding from the surface of the skin, with small yellowish-white pustules visible at the tip, and there will be obvious pain. 2. Time of onset: (1) syphilis is a chronic skin disease, but also a sexual contact as the main transmission pathway of the disease, the time of the rash can last about 2~3 months (2) Folliculitis, as an acute infectious disease, usually heals in about a week. However, the main differentiation between syphilis and folliculitis still needs to rely on syphilis serologic tests, such as syphilis-specific antibody test and syphilis non-specific antibody test. The results are positive in patients with syphilis. Due to the individual differences in clinical presentation, laboratory tests are the main point of differentiation. For specific cases, it is necessary to visit a hospital in time for an interview with a doctor.