Ankle sprain six weeks still feel pain in the affected area, considering that there may be soft tissue injury has not healed, or there are ligament rupture or even ankle fracture, with no timely diagnosis and treatment, poor fracture recovery or improper care measures and other reasons. 1. Soft tissue injury: after ankle sprain, mild injury can be gradually relieved by bed rest for 1~2 weeks, serious injury needs cast or brace to fix and brake, avoid weight bearing, such as premature activity on the ground or not fixed to protect the joints, which may affect the recovery of the condition, and the pain of the affected area. 2. Ligament rupture: after ligament rupture, you need to rest immediately, brake the affected limb, actively check in the hospital, perform surgery after clear diagnosis, and perform ligament suture repair, if you don’t treat the injury, the ligament rupture can’t be repaired, and the pain in the affected area may still occur. 3. Ankle fracture: If ankle fracture occurs, mild cases need to be fixed by plaster or brace, bed rest for 6~8 weeks before going down to the ground, serious fracture also needs surgical treatment, if the correct standardized treatment is not carried out, or even premature weight bearing, the pain in the affected area will still occur. If the ankle sprain six weeks still feel pain in the affected area, it is recommended that the patient go to the hospital in time to further identify the cause of the disease, and then targeted treatment, so as not to delay the condition.