For overweight or obese type 2 diabetic patients, if the weight can be controlled within the ideal range, it is conducive to blood glucose control, but some patients feel that weight loss is very difficult, which on the one hand may be the patient’s diet and exercise with bad. This is because weight loss necessarily requires patients to consume less calories than they consume, i.e., they need to eat less and move more to achieve a negative energy balance in order to lose weight. Patients will need to control their diet more strictly and exercise as much as their body allows. If the patient is using insulin, especially short-acting or premixed insulin, because insulin is a hormone that promotes protein and fat synthesis, if the patient’s diet is not strictly controlled, not only will the patient’s weight increase instead of decrease during the use of insulin. Some patients often have hypoglycemia during the use of insulin, and after the occurrence of hypoglycemia, they will add meals in order to correct the hypoglycemia, and their weight will not easily decrease in the long run. If the patient is using sulfonylurea or glinide hypoglycemic drugs, these two types of hypoglycemic drugs also promote insulin secretion, which will also increase the amount of insulin in the body, if the amount of medication is not appropriate or diet and exercise with poor, will also make weight loss is not easy. Therefore, if type 2 diabetes patients want to make weight loss, on the one hand, diet should be controlled and exercise should be strengthened; on the other hand, on the choice of glucose-lowering drugs, try to choose glucose-lowering drugs that do not increase weight.