Impotence and premature ejaculation are two different male sexual dysfunctions, so the medications used to treat them are different. Impotence can be treated with PDE5 inhibitors such as sildenafil, while premature ejaculation can be treated with 5-hydroxytryptamine reuptake inhibitors such as dapoxetine. Impotence is defined as erectile dysfunction of the penis. Drugs for treating impotence, generally using PDE5 inhibitors, which are effective, convenient and have mild side effects, include sildenafil, vardenafil, tadalafil and avanafil. Of these, tadalafil has a longer duration of action, and vardenafil and avanafil have a faster onset of action. Premature ejaculation is rapid or premature ejaculation. For the treatment of premature ejaculation medications, selective 5-hydroxytryptamine reuptake inhibitors are generally used, with paroxetine, fluoxetine, dapoxetine and so on. If the symptoms of impotence and premature ejaculation occur, it is recommended to consult a doctor in time, timely treatment, and use medication under the guidance of a professional physician.