Short-term glucocorticoid use as prescribed by the doctor generally has no particular effect on the testes, while long-term glucocorticoid injections can affect testicular function, especially on reproductive function. Glucocorticoid is a hormone secreted by the adrenal gland, which is involved in the body’s metabolism, immunity and the regulation of growth and development. It is mostly used for anti-inflammatory and immunotherapy in clinical practice. Generally short-term compliance with the doctor’s instructions for the reasonable application of such drugs will not cause too much impact on testicular function. However, long-term application of glucocorticoids can make the testicular spermatogenic epithelial cell gap expansion, various spermatogenic epithelial cells and support the destruction of inter-cellular connectivity structure, will affect the normal testicular blood-testis barrier, so that the normal microenvironment is damaged. Therefore a lot of harmful substances can not be shielded, osmotic pressure changes, so that water into the cells to form many vacuoles of varying sizes, will seriously affect the function of the testicles. If you want to apply glucocorticoids for a long time, you need to apply them reasonably under the guidance of your doctor.