Puffy eyes when waking up every morning are usually caused by local blood reflux disorder, allergy, kidney or heart diseases. 1. Local blood reflux disorder: If the patient has the habit of sleeping in prone position, it will lead to pressure on the eyelid area, and the local blood and lymphatic fluid reflux will be blocked, which will easily cause eyelid edema. Generally, it can be relieved after resting and does not need special treatment. 2. Allergy: If the patient is allergic to the cotton wool, dander and mites attached to bedding, it is possible to trigger an allergic reaction in the eyelid area, resulting in eyelid swelling. 3. Kidney or heart disease: Kidney disease patients will reduce urination due to renal insufficiency and decrease in albumin, resulting in edema, which is more obvious in the eyes. Heart disease patients because of cardiac insufficiency, poor peripheral blood return, resulting in edema of the surrounding tissues, which is manifested as eye edema. It is recommended that patients with significant eyelid edema should seek prompt medical attention to evaluate their condition and follow the doctor’s instructions for treatment.