The causes of leukemia are related to ionic rays, chemical substances, viral infections, and genetic factors. There are clear triggering factors for leukemia, mainly including the following: 1. Ionic rays: exposure to rays due to medical needs, non-ionic radiation such as radon, cosmic rays and electromagnetic waves in the environment may increase the risk of leukemia. 2. Certain chemicals: such as benzene and its derivatives, smoking, alcohol consumption, hair dyes, exposure to rubber, paints, antiseptics, insecticides, ethylene oxide and gasoline can increase the risk of leukemia. 3. Viral infections: For example, EBV is associated with leukemia, diffuse large B-cell lymphoma in immunodeficient patients, Hodgkin’s lymphoma and a few T-cell lymphomas. 4. Genetic factors: the influence on the pathogenesis of leukemia is significant, and it has been reported in the literature that multiple cases of leukemia can occur in a family or in the same family successively. Leukemia may also be related to other factors, and it is recommended to standardize the treatment in time after a clear diagnosis.