Nutritional changes in the skin of the lower extremities is one of the symptoms of primary lower extremity deep venous valve closure insufficiency, which mostly occurs in people who are persistently engaged in physical labor or standing workers, and has a higher incidence in farmers, hairdressers, athletes, surgeons, and other people. Primary nutritional deficiency is a simple intake deficiency, either of individual nutrients or of several nutrients at the same time. Normal human nutrition and metabolism is an important material guarantee for the health of the body. Once nutrition and metabolism are impaired, not only will the various systems of the body be damaged to varying degrees, but also a series of skin changes and damages will occur. However, secondary nutritional deficiencies and metabolic disorders still occur due to certain diseases, changes in the living environment, the influence of poor lifestyle habits or medication factors such as chronic diarrhea or long-term use of isoniazid drugs. The causes and manifestations of different nutrient deficiencies and metabolic disorders are different.