Itchy legs in uremia are considered to be related to excessive toxins in the body, hyperparathyroidism, allergies and other factors. 1. Excessive toxins in the body: patients with uremia due to impaired kidney function, the body’s toxins can not be discharged in a timely manner, gathered in the body, stimulating the local sensory nerve endings, which may lead to itchy legs or the whole body. 2. Hyperparathyroidism: uremia and other patients with further aggravation of the condition or secondary hyperparathyroidism, if there is obvious high phosphorus, high calcium, high parathyroid hormone levels, may lead to skin calcification, can cause itching. 3. Allergy: itself is belongs to the allergic body, by food, drugs and other factors or mosquito bites, may lead to leg itching. If patients with uremia have itchy skin, it is recommended to go to the hospital for relevant examinations to identify the cause and follow the doctor’s instructions for treatment.