There are many reasons for pain before urination and no pain after urination, and it is necessary to find the cause of the cause first, and then treat the cause, including the application of levofloxacin, doxazosin, or surgical treatment. 1. Urethritis: the treatment of urethritis is mainly based on anti-infection, you can take anti-infection drugs, such as levofloxacin, azithromycin, doxycycline and so on. If the patient has urethral stenosis, it is necessary to lift the urethral stenosis through surgery. 2. Urethral calculi: Urethral calculi treatment is based on surgical treatment, but the operation needs to be based on the location of the stone, size, and the surrounding urethral tissue lesions, choose the appropriate surgical method. 3. Penis: Penis treatment is based on surgery, and the common type of surgery is circumcision. There are many other reasons for pain before urination and no pain after urination, and it is recommended that patients go to the hospital as soon as possible for timely medical treatment.