Pegabine interferon, also known as polyethylene glycol interferon alpha-2b injection, is used to treat chronic hepatitis B, chronic hepatitis C, and more. Polyethylene glycol interferon alpha-2b injection is indicated for the treatment of chronic hepatitis B in adults. However, it is contraindicated when the patient is in a period of hepatic decompensation, and the diagnosis of chronic hepatitis B must be confirmed by serum markers. Polyethylene glycol interferon alpha-2b injection is also indicated for the treatment of chronic hepatitis C. Again, it is contraindicated in patients with hepatic decompensation. Treatment should be combined with ribavirin. The most common adverse reactions to polyethylene glycol interferon alpha-2b injection include fever, malaise, arthralgia, myalgia, headache, dizziness, loss of appetite, nausea, alopecia, decreased neutrophil count, gingival bleeding, chills and heat intolerance, and elevated alanine aminotransferase. Therefore, it must be used under the guidance of a specialist.